With the expansion of digital technologies in work environments, the nature of work processes and organizational interactions has undergone substantial transformation. Therefore, the present study aims to systematically synthesize and analyze empirical findings through a meta-analytic investigation of the consequences of digital fatigue in the workplace.The study employed a meta-analysis approach. To identify relevant studies, a systematic search was conducted in both national and international scientific databases. Ultimately, seven relevant articles were selected, from which seventeen independent effect sizes were extracted. These studies were published between 2016 and 2025 and collectively included a total sample of 4,334 participants. Effect sizes were calculated using Pearson’s correlation coefficient and analyzed with the Comprehensive Meta-Analysis (CMA) software under a random-effects model.The results indicated that digital fatigue has a significant negative relationship with performance-related outcomes (r = −0.432). Furthermore, its relationship with psychological outcomes and mental strain was also negative and significant (r = −0.391). However, the relationship between digital fatigue and individual and organizational resources was not statistically significant (r = −0.294). The heterogeneity test results also revealed significant heterogeneity among the included studies. Overall, the findings suggest that digital fatigue can have substantial negative effects on employees’ performance and psychological well-being.